With 2 picks, Hornets eagerly await lottery fate

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Apartment Careers: Real Estate/Property Management jobs ...

About Pinnacle.

We invest in great people. That's why clients trust us with their real estate investments!
At Pinnacle, we consider our employees our most valuable asset. In fact, our number one key business objective is to attract and retain the best talent in the industry! At Pinnacle, the key to our continued success and competitive advantage is our people.

We offer a total compensation and benefits package to help with your needs today and build for your future tomorrow. We recognize that each employee is an individual with individual needs, lifestyles, and interests. Our benefits package was created with the flexibility to support employees who are at different places in their lives and careers.

Pinnacle values diversity and is committed to equal opportunity in employment. We offer a safe, healthy work environment for employees through a commitment to maintaining a drug-free workplace.
Pinnacle has ongoing employment opportunities at our headquarters in Seattle, our more than 40 branch office locations nationally and our many managed communities throughout the country.

Pinnacle is the national leader in third-party fee management of investment real estate encompassing multi-family, commercial space, affordable housing and military housing. Pinnacle is built on four basic principles:

Quality people

Strong customer service

Solid market knowledge

Superior systems and support capabilities

At Pinnacle, success is about more than having a healthy bottom line. Guided by our principles and values, we are committed to making Pinnacle an amazing and unique place to work for each member of our team.

About the job..

As a Maintenance Technician at Pinnacle, you play an important role onsite Maintenance staff. A Maintenance Technician is a hands-on professional who acts under the direction of the Service manager and performs installations, repairs, and replacements for a multi-million dollar apartment community. Your job is vital to the satisfaction of our residents because appearance of the property and maintenance operations is one of the biggest reasons residents choose a Pinnacle managed property to call home. At Pinnacle, we value our Maintenance Staff, provide career training, and a clear career path for individuals who are looking for advancement opportunities.
Our Maintenance Staff are the backbone of our apartment communities. Theyre responsible for keeping our communities in the top-notch condition our residents have come to expect, building motivated and trustworthy teams who consistently deliver a notably higher level of service to our residents. Be ready to be busy!

Essential Responsibilities:

Under the director of the Maintenance Supervisor, the Maintenance Technician will be responsible for ensuring that the physical aspects of the property meet the company's established standards and any applicable laws.

Must diagnose problems and make repairs in areas such as HVAC, electrical, plumbing, pool, exterior and appliance.

Personal Competencies:

High-energy

Roll up your sleeves mentality

Warm, friendly and service-oriented philosophy

High degree of flexibility and tolerance for change

Effective written and verbal communications skills

Organized and detail-oriented

Customer-service focused

Qualifications:

Minimum of a high school diploma

2+ years of on-site property management/facility maintenance experience

Excellent oral and written communication skills

Must be knowledgeable of OSHA regulations

Must have HVAC certification

Must have a valid drivers license and be able to drive

Must be willing to work evenings or weekends (on call) in the case of an emergency

Pinnacle has grown to become America's largest apartment manager through many different successes. Yet, in today's ultra-competitive market, each success must fuel the next and speed is essential in the ongoing race to lead the industry.

If you are ready to work hard and be empowered and encouraged to innovate, contribute ideas and discover solution to provide current and potential residents with unparalleled, world class customer service please click Apply Online.

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Wisconsin's Walker widens lead in recall election: poll (reuters)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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Blue-green algae release chemical suspected in some amphibian deformities

Retinoic acid levels high in waterways rich in cyanobacteria blooms

Web edition : 5:41 pm

Harmless as they may look, some of the microbes called cyanobacteria have the power to dose waterways with a range of chemicals that might cause deformities in frogs or other vertebrate wildlife.

Cyanobacteria, also called blue-green algae, could be an underappreciated but widespread source of compounds called retinoic acids in waterways, says environmental toxicologist Jianying Hu of Peking University. Out of 24 kinds of cyanobacteria grown in a lab, 13 produced some kind of retinoic acid or retinoic acid cousin, Hu and her colleagues report online May 29 in the Proceedings of the National Academy of Sciences.

Retinoic acids, formed from vitamin A, help sculpt developing body parts in vertebrates. Researchers puzzling over clusters of deformed frogs first highlighted in the 1990s have considered retinoic acids as one of several possible villains.

Hu and colleagues also analyzed samples from China?s third largest freshwater lake, Taihu Lake, which is rich in cyanobacteria blooms. The lake carries high concentrations of retinoic acids, the researchers found.

The new work ?opens up a new area of potential research,? says plankton ecologist Karl Havens, who directs the Florida Sea Grant College Program in Gainesville. ?I will be interested now to see if the compounds are found in other lakes with cyanobacteria blooms, or even if they continue to be documented in this lake,? he says.

The retinoic acid concentration found in Taihu Lake ? up to 20 nanograms per liter ? was 10,000 times what Kunimitsu Kaya of the University of Tsukuba in Japan and his colleagues have found in Japanese lakes. Last year Kaya reported cyanobacteria making a retinoic acid cousin (7-hydroxy retinoic acid); he says he finds it plausible that blooms create such extreme conditions in Taihu. Scum there probably blocks sunlight that otherwise would break down some of the very potent retinoic acids.

There?s not enough information yet to link cyanobacteria to high rates of amphibian deformities, says ecologist Andrew Blaustein of Oregon State University in Corvallis. He and other researchers have proposed a variety of other possible contributing menaces, including UV radiation and trematode parasites.

Parasites, a leading hypothesis for the cause of some limb abnormalities, certainly don?t explain all the cases, says disease ecologist Pieter Johnson of the University of Colorado Boulder. The new paper ?may be a useful step forward in helping to explain abnormalities in wetlands without the parasite.

Found in: Ecology, Environment and Life

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Demi Lovato Opens Up About Bipolar Disorder

'I felt relieved when I found out,' 'X Factor' judge tells Cosmopolitan in July issue.
By John Mitchell

Demi Lovato
Photo: Cosmopolitan

Demi Lovato is opening up about her bipolar disorder in the July issue of Cosmopolitan, telling the magazine that being diagnosed was a relief because it meant she could treat the problem.

"I felt relieved when I found out. Like I'm not completely crazy; there's a medical reason for all of it," Lovato says in the July issue. "It's a daily thing; you don't get time off from it. And if I feel myself slipping back into old patterns, I have to ask others for help, which is hard for me to learn, because I really like doing everything on my own."

The new "X Factor" judge revealed earlier this year in her MTV documentary that her issues manifested themselves in self-harm, including an eating disorder and self-medicating that resulted in a stay at the Timberline Knolls treatment facility in Illinois.

"I had so many issues that were underneath, that needed to be taken care of, and we kept putting Band-Aids over it. It literally drove me insane. I was not eating, and purging, and self-harming. It was really difficult to be able to stop," Lovato recalled to MTV. "This is a daily battle that I will face for the rest of my life. Everyone kind of made me a role model, and I hated that. I was partying, I was self-medicating. I was always stressing out. I felt like I was living a lie. I felt guilt and shame. I decided to take it out on myself. I harmed myself. It was my way of taking my own shame and my own guilt out on myself, and I was just depressed."

Having gotten the help she needed and with her new high-profile gig on "The X Factor" opposite Britney Spears, the pop star is back on the right path now, and she tells Cosmopolitan that she sees herself with a family in the not-too-distant future. "I want to be married with kids in 10 years," Lovato revealed.

The 19-year-old singer/actress' past struggles have given her a new perspective on dating as well, teaching her that she should not rush to judgment when it comes to guys — with the exception of one characteristic that she simply will not abide.

"I don't have many deal breakers. I've done so much in my life, it doesn't feel right to judge other people," Lovato tells the mag. "Oh, I know one quality I won't tolerate. I would never be with a guy who is controlling."

Related Videos

• 'Demi Lovato: Stay Strong'

Related Artists

• Demi Lovato

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Pakistan jails doctor who helped find bin Laden: why the US may not intervene

The doctor who helped the CIA find Osama bin Laden has been sentenced to 33 years in jail. But perhaps?US-Pakistan relations have fallen so low that the US doesn't care anymore.?

By Scott Baldauf,?Staff writer / May 23, 2012

Pakistani men walk by the Central Jail in Peshawar, Pakistan, Wednesday, May 23. A Pakistani doctor who helped the CIA find Osama bin Laden has been sentenced to 33 years in jail.

Mohammad Sajjad/AP

Enlarge

A Pakistani tribal court has found the Pakistani doctor who helped the CIA effort to locate Osama bin Laden guilty of treason, and sentenced him to 33 years in prison.

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To Pakistan, Shakil Afridi is a traitor who helped a foreign power locate and kill an enemy on its territory. To the US, Dr. Afridi is a hero who will now, apparently, spend the next 33 years of his life in prison.

The US lobbied hard with the Pakistani government to gain Afridi?s release. US Secretary of Defense Leon Panetta, during a February 2012 visit to Islamabad, urged Pakistani authorities to release Afridi, but Pakistan declined. Given the substantial public anger in Pakistan over the bin Laden killing ? more about the US?s violation of Pakistani sovereignty than for sympathy for the man ? Pakistan sealed Afridi?s fate.

Now his sentencing marks another low-water mark for the US-Pakistani relationship, and highlights how little common ground the two countries share. But expectations for each side are now so low that it?s unlikely the US is going to adopt another full-court press as seen when another US spy ? Raymond Davis ? faced detention in Pakistan.

Think you know Asia? Take our quiz?

To be sure, Afridi?s Pakistani nationality also means the US isn?t going to view his detention in quite the same leave-no-man-behind terms. And the US does not have the same legal arguments of the Geneva Conventions as it did in the case of Mr. Davis.

But there?s also much less riding on the US-Pakistan relationship than even a year ago when the Davis affair erupted. NATO has managed to keep the Afghan war effort going, despite Pakistan cutting off supply lines through its territory. Then, too, trust has evaporated since the discovery of bin Laden in Pakistan and the unauthorized US raid to kill him.

Roller coaster ride

America has had a roller coaster relationship with Pakistan for years. In the 1980s and early 1990s, the US and Pakistan were as thick as thieves, funding, arming, and training Afghan and Pakistani fighters to take on the Soviet occupation of Afghanistan. After the Soviets withdrew, and after Pakistan successfully tested a nuclear device, the US imposed strict military sanctions against Pakistan, and left that country with tens of thousands of former militants, thousands of politically charged Islamic seminaries, and a Pakistani economy addicted to foreign aid.

Today, the US and Pakistan have spent a decade ostensibly fighting on the same side against Islamist extremist groups ? some of whom use Pakistan?s less-well-controlled corners, such as Swat and Northern Waziristan, as their bases ? and yet it is not clear how much these two countries share in common anymore.

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Intel details 14 dual-core Ivy Bridge processors ahead of Computex

Intel announced its quad-core Ivy Bridge processors in April, but we've known that dual-core CPUs must be on the way too. And alas, the chip maker does have some up its sleeve -- 14, to be exact. Core i5 and Core i7 versions will be the first to ship, with Core i3 processors launching later this year along with new Pentiums and Celerons. Of the 14 dual-core processors, six are desktop-grade. The rest are mobile, though four are ultra-low voltage (which will be denoted by a U at the end of their name). Computex is just around the corner, and we expect to see plenty of Ivy Bridge systems -- especially Ultrabooks with ultra-low voltage CPUs -- there next week. In the meantime, we've already reviewed the Lenovo ThinkPad x230, a system running a dual-core 2.6GHz Core i5 Ivy Bridge processor. If you're into the nitty-gritty details, you'll find plenty to love in the Intel slides below the break.

Continue reading Intel details 14 dual-core Ivy Bridge processors ahead of Computex

Intel details 14 dual-core Ivy Bridge processors ahead of Computex originally appeared on Engadget on Thu, 31 May 2012 00:01:00 EDT. Please see our terms for use of feeds.

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Important Factors to Consider when Hiring a Dubai Web Design Firm

Due to major advancements in technology, many businesses are now using the Internet to market and sell their products or services. On the surface, this might appear to be a straightforward endeavour, but the opposite is always the case.

Due to major advancements in technology, many businesses are now using the Internet to market and sell their products or services. On the surface, this might appear to be a straightforward endeavour, but the opposite is always the case. Thus, it is prudent to enlist the help of a competent Dubai web design firm, which has the experience and expertise, to create a functional and lucrative website. Consequently, there are a number of factors one should bear in mind when picking the right Dubai Web development firm. One sure method of appraising the capability of a Dubai Web design is by going through their previous work.

Most of these Dubai Web development companies will provide a wide range of catalogues to their client?le exhibiting their various products. This can be of great import in aiding potential clients in gauging the adeptness of a Dubai Web development firm, and whether it measures up to ones preconceived standards. Thus, anyone contemplating hiring such a Dubai Web design company should insist on reviewing their past projects before committing themselves. Another critical aspect that one should contemplate before choosing the best Dubai Web development firm, is the projected time the firm might require to build the website.

One should insist on an honest appraisal of the web designing schedule which factors in any unexpected occurrence. Ideally, since many businesses utilize the web to market and sell their products and services, it is vital to have ones website ready in the shortest time available. However, caution is advised when dictating the duration needed for the entire Dubai Web Design process, so that the firm can have the ample time needed to avoid a shoddy job.

Another vital factor that can help one determine which Dubai Web development firm to pick is the cost they set for the entire project. As most businesses operate on a tight financial leash, it is critical for one to review the prices of several probable firms before determining which one will be appropriate. One should always insist on been given a clear cost breakdown of every phase of the Dubai Web design project. Additionally, it is also of great import for one to comprehend the package he or she will get from the firm. Some firms integrate follow up consultations in the overall price, which can be a huge benefit to the clients.

Another factor to consider when contemplating Dubai Web development is the firm?s experience and reputation. Firms that are firmly established, tend to have more experience, and will most definitely have gained an excellent reputation in all its dealings. However, one drawback on such Dubai Website design firms is that, for the most part, they will always demand higher costs than newer firms. The final factor to comprehend when choosing the right Dubai Web design firm is its customer relation prowess. A client that is coughing up money will want to be assured that the Dubai Website development firm they pick, has the expertise to ascertain what he or she needs.

Resources:
iBaroody is the author of this article on Web design Syria.
Find more information, about Web development Syria here

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A Quick Guide To Condo Buying | FINANCE-DEBT RELIEF

Condominiums have increased in demand over the final two decades. The small upkeep that is required is very attractive to quite a few buyers. The limited upkeep and lower price tag entice property owners. Quite a few condo complexes provide entertainment and social activities as well as exercise facilities. Think of your needs and lifestyle just before you buy a condo.

Instead of becoming a mode of building, a condo is much more of a sort of ownership. Low-rise buildings, townhomes, and houses may also be condo properties. You will find two components to condominiums, the apartment itself and the common zones. A home owner will buy a particular unit that will be documented in his or her name. The common sections such as recreational facilities, elevators, hallways, etc are properties of all apartment owners. You?ll find however a handful of common components which are limited to certain unit owners. Forms of common elements enjoyed by an exclusive owner consist of lockers, vehicle parking spaces as well as balconies. There could be limitations connected with a number of the exclusive common components so be sure to enquire about them.

Find out about the rules, bylaws and polices in place in the condo building that interests you and remember that polices for condos may vary from nearby metropolitan areas. These may either be laid back or very strict based on the condo corporation. Modifications to the appearance of the unit, car parking, noise and pets are all items which might be restricted. There are resale condo properties, conversions and new constructions offered to you. Numerous potential buyers are enticed by new developments as they supply better possibilities with regards to unit locale, finishing options, new home warranty protection, and so on. You should realize nevertheless that modifications may take place in the course of the development period and so the your condo might not look precisely as it did on the plan.

The main distinction with a condominium conversion and a new build is the fact that the outside of the building is already set up. Quite a few of the benefits of conversions are the same as for new condominiums. The provincial system of home warranty protection might or may not pertain to a condo conversion and needs to be confirmed.

A resale condominium will appeal to those who prefer to view the units and the amenities before they make one final selection. Unlike brand new constructions, resale condos often have a lot more square footage. On the other hand, you might need to remodel an older apartment and your choice of place could be limited.

Before making your final decision, recruit the help of professionals with experience in condominium property and realize that a leading real estate agent who specializes in houses additionally needs to totally comprehend the condominium industry. An experienced real estate agent will help you save time and capital. A real estate attorney with knowledge regarding condominiums will help protect your legal interests. Uncover any prospective problems with the condo unit and structure with the assistance of a home inspector. Last but not least, remember to discuss your choices with a financial advisor that will safeguard your money.

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'Snow White And The Huntsman' Didn't Require Much Training, Says Kristen Stewart

When you watch "Snow White and the Huntsman," there's little doubt that the characters on the screen know what they're doing. They can wield two axes at the same time. They know how to ride horses. They can suck the youth out of helpless peasants. (Maybe not that last one.) So it was a surprise [...]

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Judges to pass sentence on Charles Taylor

LEIDSCHENDAM, Netherlands (AP) ? Judges are passing sentence on former Liberian President Charles Taylor for supporting rebels in Sierra Leone who murdered and mutilated thousands during their country's brutal civil war.

Taylor was convicted last month on 11 charges of aiding and abetting the rebels who went on a bloody rampage during the decade-long war that ended in 2002.

The 64-year-old warlord-turned-president is the first former head of state convicted by an international war crimes court since World War II.

Prosecutors have asked judges at the Special Court for Sierra Leone to impose an 80-year sentence when they mete out his punishment Wednesday morning. Taylor's lawyers urged judges to hand down a sentence that offered him some hope of release before he dies.

Taylor will serve his sentence in a British prison.

Associated Press

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ADATA lets the sun shine on its new range of Premier Pro microSD cards

ADATA's trio of new Premier Pro microSD cards have escaped from the company's headquarters. Aimed at professionals and demanding consumers, the 16GB and 32GB editions come with a 45MB/s read and 40MB/s write speeds and support the latest SD 3.0 standard. The company isn't mentioning how well the 8GB card runs, so we'll just presume it's a little less speedy than either of its larger brothers. We've reached out to the company to find out when we can expect to see these hitting shelves (and how much they'll cost) and we will update if they tell us.

Continue reading ADATA lets the sun shine on its new range of Premier Pro microSD cards

ADATA lets the sun shine on its new range of Premier Pro microSD cards originally appeared on Engadget on Wed, 30 May 2012 21:47:00 EDT. Please see our terms for use of feeds.

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The Tools in the Box - The Chronicle of Higher Education

We?re still slamming around in the gale unleashed by my lighthearted survey of last week. But since results are still trickling in, I will not yet attempt any synthesis of results or responses to the very nature of the game. Instead, please consider this an extended footnote from my peculiar domain of academe, which is the doing and teaching of fiction writing.

I fully expect comments that question what the academy is doing messing around in the realm of creative writing in the first place, but I hope the discussion doesn?t get pulled in that direction. Here I?d like to stick to word choice, syntax choice, grammar choice.

In Sunday?s Modern Love column in The New York Times, I ran across the sentence ?He didn?t even know I hadn?t smoked or drank in 10 years.? I read it aloud over breakfast, and it didn?t jar my partner. But it jarred me. Strictly speaking, the reason to take umbrage at the column is the opinion that ?I had drank? is incorrect. The verb conjugates as ?I drink; I drank; I have drunk.? Of course the word ?drunk? might imply drunkenness, and it may well be that the author or editor changed ?I hadn?t smoked or drunk in 10 years? because she guessed that readers would conjure an image of the author as a slovenly drunkard. If that guess is accurate, then the sentence may be better in its current form, an alternative to traditional conjugation.

But what remains jarring to me about that form is that a narrator who says, ?I had drank that wine? or ?I drunk it right down? gives himself away (or so we fiction writers presume) as belonging to one of several social types and not to others. Other markers?use of ?y?all? or ?ain?t,? or ?that hossie better get along? would help indicate whether the same narrator is from the deep South or the deep North, or a cowboy, or a dude rancher, or a preppie making fun of other social types, or Lord knows what else. The choices are myriad; ?drank? is the tip of the iceberg.

But that iceberg is the stuff of the fiction profession, and those of us who teach in that profession try mightily to instruct our students in the deft use of their linguistic tools. For a while, this effort for me included laying out the traditional conjugation of transitive ?lay? versus intransitive ?lie.? If you inadvertently have a persnickety grammarian-type character saying, ?I need to lay down,? this argument went, you are giving the reader mixed signals, whether or not the reader is aware of how the verbs are parsed. By contrast, if you want to demonstrate the scanty education of your perfidious murderer, you might have him write his confession with a solecism like ?He just lied [or layed] there.? However, in a number of recent novels, I?ve noticed that otherwise exemplary fictional speakers of standard English are using ?lay? intransitively. If this usage shift becomes universal, we fiction writers will have lost a tool from our toolbox, and there will no further point in teaching students how to deploy it. That, more than right/wrong or descriptive/prescriptive dichotomies, is our main concern.

In my latest novel, I have a meth addict who is getting fired say of work that day, ?I shouldn?t of come in?; and of a love interest, ?If I could of had her, I would of.? My copy editor changed these locutions to ?could have? and ?could?ve.? I read the various versions aloud; I tried to tell myself there was no auditory difference between ?shouldn?t of? and ?shouldn?t?ve?; I tried to rationalize that even though this particular meth addict might write ?could of,? he is not writing but speaking in the scene. In the end, I restored ?of,? hoping that my readers would hear my character better that way and would not assign the solecism to the author.

Artists need to know their paints, their brushes, their canvases; composers need to know keys, scales, harmony, meter. Fiction writers and poets need to know language, in as many registers as possible, to create worlds made entirely of words.

P.S. Wed. morning ? I have updated the penultimate paragraph to clarify what was confusing to some readers.

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Shakil Afridi, Pakistan Doctor In Bin Laden Hunt, Found Guilty Of Militancy, Not CIA Links

PESHAWAR, Pakistan -- A Pakistan doctor who assisted the CIA in tracking down Osama bin Laden was sentenced to 33 years in prison for conspiring with an Islamist militant commander, a verdict that will make it more difficult for Washington to argue for his release.

The judgment against Shakil Afridi debunked the widely held assumption that he had been convicted for his involvement with the American spy agency.

The decision referred to unspecified evidence that Afridi had "acted" with foreign intelligence agencies, but went on to say any charges related to that couldn't be considered because the court didn't have jurisdiction. The Associated Press obtained a copy of the five-page document, first reported by Pakistan's Dawn newspaper, on Wednesday.

Earlier this week, Afridi's family and lawyers said he was innocent and would appeal. They said they had not yet seen the court verdict and refused to comment on his relations with the CIA. The trial was carried out in a court in the country's tribal regions close to Afghanistan. A political official, in consultation with tribal elders, ruled on the case in secret.

The United States has called for Pakistan to release Afridi, and his punishment has become another flashpoint issue in the fractured relations between the two countries. Pakistan's army was outraged by the unilateral U.S. raid that killed bin Laden in May 2011 because it was a violation of the country's sovereignty and added to perceptions it was a sponsor of terror.

Afridi ran a vaccination campaign on behalf of the CIA to collect blood samples from bin Laden's family at a compound in Abbottabad where U.S. commandos killed the al-Qaida leader. It was unclear whether he succeeded, but U.S. officials have publicly said he helped the effort to track bin Laden.

The fact Afridi was technically convicted for militancy, not helping the CIA, could complicate Washington's efforts to press for his release. Pakistan could argue that his trial was an internal matter that has nothing to do with the United States.

The verdict said Afridi was guilty of conspiring with a militant group led by commander Mangal Bagh. It said he gave money to the group and treated its leaders at a hospital in Khyber when he was stationed there. According to unnamed witnesses, he did this because of his "deep affiliation with the group." Others, also unnamed, said the group planned terrorist attacks in Afridi's office.

The verdict, which was passed down last week, found Afridi guilty of "conspiring against the state" and other charges.

Pakistani officials didn't attempt to correct widespread reports that the charges referred to his work with the CIA. The verdict triggered anger in the United States and elsewhere, with many questioning how helping kill bin Laden ? a sworn enemy of Pakistan ? could be seen as working against the state.

The full text of the verdict means Pakistan can now, technically at least, deflect that criticism.

Afridi's motivation for working with the CIA or whether he was aware who was employing him has never been established. He was once the top medical officer in the Khyber region.

Speaking last week, a friend said he had once been kidnapped by Mangal Bagh's group and paid a heavy ransom for his release. The friend didn't give his name because he didn't want to attract attention to himself.

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Bin Laden case doctor jailed for militant link

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LA BioMed's Dr. Patricia Dickson researching treatments for neurodegenerative disorders

Public release date: 30-May-2012
[ | E-mail | Share ]

Contact: Diana Soltesz
diana@dsmmedia.com
818-592-6747
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

California Institute for Regenerative Medicine awards $5.5 million grant for project

LOS ANGELES (May 30, 2012) Patricia Dickson, M.D., principal investigator at The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), is co-principal investigator of a project that was just awarded a $5.5 million grant from the California Institute for Regenerative Medicine (CIRM). The goal of the project is to develop a stem cell based therapy for the treatment of mucopolysaccharidosis I (MPS I), a fatal pediatric lysosomal storage disease that causes neurodegeneration as well as defects in other major organ systems. Dr. Dickson is working with lead investigator Philip H. Schwartz, Ph.D., senior scientist at the CHOC Children's Research Institute and managing director of the facility's National Human Neural Stem Cell Resource.

For nearly a decade, Dr. Dickson's research at LA BioMed has focused on enzyme replacement therapy for mucopolysaccharidosis, a group of metabolic disorders caused by the absence or malfunctioning of enzymes needed to break down molecules - called glycosaminoglycans - which help build bone, cartilage, connective tissue and other essential parts of the body. As part of this study, she and her colleagues will begin with proof-of-principle experiments for MPS I.

"Dr. Dickson has been at the forefront of mucopolysaccharidosis research for many years, working tirelessly to help develop therapies for MPS I," said David I. Meyer, Ph.D., president and CEO of LA BioMed. "We congratulate her on her continued success, and for her role in this project which could be an important breakthrough for children suffering from neurodegenerative disorders."

"The unique aspect of this research is that it uses a single donor for the transplantation of stem cells into the body and the brain, which allows the best treatment for both physical and neurological disease and avoids rejection of neural stem cell grafts by the host immune system," said Dr. Dickson. "Pediatric neurodegenerative diseases are generally neglected in stem cell research, but stand the greatest chance of success. The high probability of success, along with the need to alleviate suffering in children, is why we believe the first applications of stem cell therapies should be for these kids."

Dr. Schwartz, Dr. Dickson and project collaborators are working to address two critical issues in the development of a therapeutic candidate based on stem cells: that early intervention is not only required but is indeed possible in this patient population, and that the concept of immune tolerance is also required, where the immune system is trained to attack only real threats in the body but not the body's own cells or tissues.

To date, there is still a significant unmet medical need to better impact and prevent the neurodegenerative processes in this disease. If successful in MPS I, this technique can be expanded to help treat other neurodegenerative disorders due to lysosomal storage.

###

About LA BioMed

Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into improved treatments and cures for cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit www.LABioMed.org

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 30-May-2012
[ | E-mail | Share ]

Contact: Diana Soltesz
diana@dsmmedia.com
818-592-6747
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

California Institute for Regenerative Medicine awards $5.5 million grant for project

LOS ANGELES (May 30, 2012) Patricia Dickson, M.D., principal investigator at The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), is co-principal investigator of a project that was just awarded a $5.5 million grant from the California Institute for Regenerative Medicine (CIRM). The goal of the project is to develop a stem cell based therapy for the treatment of mucopolysaccharidosis I (MPS I), a fatal pediatric lysosomal storage disease that causes neurodegeneration as well as defects in other major organ systems. Dr. Dickson is working with lead investigator Philip H. Schwartz, Ph.D., senior scientist at the CHOC Children's Research Institute and managing director of the facility's National Human Neural Stem Cell Resource.

For nearly a decade, Dr. Dickson's research at LA BioMed has focused on enzyme replacement therapy for mucopolysaccharidosis, a group of metabolic disorders caused by the absence or malfunctioning of enzymes needed to break down molecules - called glycosaminoglycans - which help build bone, cartilage, connective tissue and other essential parts of the body. As part of this study, she and her colleagues will begin with proof-of-principle experiments for MPS I.

"Dr. Dickson has been at the forefront of mucopolysaccharidosis research for many years, working tirelessly to help develop therapies for MPS I," said David I. Meyer, Ph.D., president and CEO of LA BioMed. "We congratulate her on her continued success, and for her role in this project which could be an important breakthrough for children suffering from neurodegenerative disorders."

"The unique aspect of this research is that it uses a single donor for the transplantation of stem cells into the body and the brain, which allows the best treatment for both physical and neurological disease and avoids rejection of neural stem cell grafts by the host immune system," said Dr. Dickson. "Pediatric neurodegenerative diseases are generally neglected in stem cell research, but stand the greatest chance of success. The high probability of success, along with the need to alleviate suffering in children, is why we believe the first applications of stem cell therapies should be for these kids."

Dr. Schwartz, Dr. Dickson and project collaborators are working to address two critical issues in the development of a therapeutic candidate based on stem cells: that early intervention is not only required but is indeed possible in this patient population, and that the concept of immune tolerance is also required, where the immune system is trained to attack only real threats in the body but not the body's own cells or tissues.

To date, there is still a significant unmet medical need to better impact and prevent the neurodegenerative processes in this disease. If successful in MPS I, this technique can be expanded to help treat other neurodegenerative disorders due to lysosomal storage.

###

About LA BioMed

Founded in 1952, LA BioMed is one of the country's leading nonprofit independent biomedical research institutes. It has approximately 100 principal researchers conducting studies into improved treatments and cures for cancer, inherited diseases, infectious diseases, illnesses caused by environmental factors and more. It also educates young scientists and provides community services, including prenatal counseling and childhood nutrition programs. LA BioMed is academically affiliated with the David Geffen School of Medicine at UCLA and located on the campus of Harbor-UCLA Medical Center. For more information, please visit www.LABioMed.org

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Parents: Sharing of Yale grad's essay is a comfort

This undated photo released by the Keegan family shows Marina Keegan, of Wayland, Mass., on the Yale University campus in New Haven, Conn. Marina, who graduated from Yale less than a week earlier, died at the scene of an automobile crash in Dennis, Mass., Saturday, May 26, 2012. Her writing had been published in The New York Times, and she had accepted a job at The New Yorker. Her final Yale Daily News column was widely shared on social media, where she had implored her classmates to "make something happen to this world." (AP Photo/Keegan Family)

This undated photo released by the Keegan family shows Marina Keegan, of Wayland, Mass., on the Yale University campus in New Haven, Conn. Marina, who graduated from Yale less than a week earlier, died at the scene of an automobile crash in Dennis, Mass., Saturday, May 26, 2012. Her writing had been published in The New York Times, and she had accepted a job at The New Yorker. Her final Yale Daily News column was widely shared on social media, where she had implored her classmates to "make something happen to this world." (AP Photo/Keegan Family)

This undated photo released by the Keegan family shows Marina Keegan, left, and her brother Pierce, of Wayland, Mass. Marina, who graduated from Yale less than a week earlier, died at the scene of an automobile crash in Dennis, Mass., Saturday, May 26, 2012. Her writing had been published in The New York Times, and she had accepted a job at The New Yorker. Her final Yale Daily News column was widely shared on social media, where she had implored her classmates to "make something happen to this world." (AP Photo/Keegan Family)

WAYLAND, Mass. (AP) ? "What we have to remember is that we can still do anything," Marina Keegan wrote to fellow Yale University graduates. "... We can't, we must not lose this sense of possibility because in the end, it's all we have."

Three days after the Yale alumna's death in a car crash, her parents, Tracy and Kevin Keegan, said from their Massachusetts home that it was comforting that even strangers were drawing inspiration from their daughter's words as her last newspaper column spread across the Internet.

"I would love my daughter's words, few as they may be, to be shared," Tracy Keegan said. "... That's all that's left of her now, her words."

Yale Daily News Editor Max de La Bruyere said Tuesday that the newspaper put Keegan's print column online as a tribute following her death Saturday on Cape Cod. He said it had gotten 400,000 hits on the newspaper's website after first spreading through Yale students' Facebook and Twitter accounts. The newspaper tracked readers as far away as Asia.

"It's a huge outpouring of sympathy," he said. "People are very moved by it."

The 22-year-old's column talked about anxiety that came with the feeling of losing the web of fellowship at Yale. She said what she wanted out of life was "the opposite of loneliness," and encouraged classmates by saying "the best years of our lives are not behind us."

"It's not quite love and it's not quite community," the English major wrote of her time at Yale. "It's just this feeling that there are people, an abundance of people, who are in this together."

The Keegans said their daughter's boyfriend, 22-year-old Michael Gocksch of Centerport, N.Y., fell asleep at the wheel while driving with her to their family's summer place in Wellfleet on Cape Cod.

The young couple had been to Brookline earlier in the day so their daughter could introduce her boyfriend and fellow 2012 graduate to her grandmother. The couple was heading to a birthday dinner for Keegan's father when she died. Gocksch was hospitalized in stable condition after the crash and later discharged.

Massachusetts State Police are still investigating the cause of the crash, which occurred on Route 6 in the town of Dennis. They said speed wasn't a factor and both were wearing seatbelts. The vehicle drifted off the road and into guardrails on both sides of the road before flipping.

Keegan's parents said she was about to start a job as an assistant to the general counsel at The New Yorker, where she interned last summer and got some of her work onto a magazine blog.

The New York Times also published a piece she wrote after another column she did for the Yale Daily News sparked a debate about why 25 percent of Yale graduates go into finance or consulting instead of pursuing employment more closely connected to their studies and aspirations.

Keegan had been the president of Yale College Democrats. She worked in New Hampshire in the summer of 2008 as one of the youngest paid staffers for the Obama presidential campaign, her parents said Tuesday while looking at a photo of their daughter with the president.

The Keegans spent graduation weekend with their daughter in New Haven, time they said they were grateful for as they prepare for her memorial Saturday at The First Parish in Wayland. They plan to spread her ashes in Cape Cod Bay.

Yale professor and literary critic Harold Bloom said Keegan had become like an adopted granddaughter to him after serving as his research assistant for the past two years. He taught her seminars in Shakespeare and American poetry and called her senior essay about the poet John Keats' influence on author F. Scott Fitzgerald's work "quite publishable."

In August, a musical that Keegan wrote will be staged in New York City as part of The New York International Fringe Festival, fellow 2012 Yale graduate and project collaborator Mark Sonnenblick said.

Called "Independents," the play is about a group of 20-somethings smuggling drugs on a Revolutionary War-era ship while posing as war re-enactors. When the posse's leader disappears, the friends try to become real re-enactors.

Sonneblick, who wrote the show's lyrics, said the script is about transitioning to adulthood and maintaining community and relationships, themes that embodied much of Keegan's writing.

"These are things Marina didn't necessarily have answers for," Sonneblick said. "She took on issues she was concerned about and happened to her and her friends."

The Yale graduate said it like this in her last column: "We're in this together, 2012. Let's make something happen to this world."

___

Online:

Keegan's essay: http://www.yaledailynews.com/news/2012/may/27/keegan-opposite-loneliness/?cross-campus

Associated Press

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Dell adds XPS One 27 with 2560 x 1440 screen to its all-in-one lineup, prices start at $1,399 (video)

HP, Sony and Toshiba have already outed their new offerings for the back-to-school season, and now Dell is stepping up to the plate with announcements of its own. First up is the XPS One 27 all-in-one. As the name would suggest, it has a 27-inch screen, and the resolution is an impressive 2560 x 1440 pixels. All configurations are going to ship with Ivy Bridge processors (Core i5 or i7) with up to 16GB of memory, and the standard 1TB 7,200RPM hard drive can be swapped out for a 2TB HDD or 32GB SSD. Meanwhile, Waves MaxxAudio 4, Infinity-branded speakers, a Blu-ray drive and optional 2GB NVIDIA GeForce GT640M GPU memory (upgradeable from integrated Intel graphics) up this machine's multimedia cred. An optional internal TV tuner will also be offered. Wrapping things up, there are four USB 3.0 sockets, two USB 2.0 ports with power charge, audio out, HDMI, VGA, mic and headphone jacks and an 8-in-1 memory card reader. The XPS One 27 starts at $1,399, and while it's available in Asia starting today, it's not expected to hit the US for a few weeks.

Gallery: Dell XPS One 27 all-in-one

Continue reading Dell adds XPS One 27 with 2560 x 1440 screen to its all-in-one lineup, prices start at $1,399 (video)

Dell adds XPS One 27 with 2560 x 1440 screen to its all-in-one lineup, prices start at $1,399 (video) originally appeared on Engadget on Tue, 29 May 2012 09:00:00 EDT. Please see our terms for use of feeds.

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1971 Oldsmobile Cutlass (Auction ID: 112649, End Time : Jun. 05 ...

Current Bid - Start Bid USD 22,900.00 [ Convert ] Quantity 1 # Bids 0 You must be registered in order to be able to bid. Seller Information Blacktie (0) Registered since Feb. 26, 2011 in United States Description 1971 OLDSMOBILE CUTLASS, When was the last time you saw a FOUR-SPEED '71 Cutlass ??? A RARE car to be sure !!! Black and silver paint with a BEAUTIFUL black bucket seat interior..... High-performance 350 / 4 barrel motor and 4 speed move this Olds VERY nicely !!! You hace to stop in and SEE this one !!!! Fast Auto Loan Shipping Conditions Buyer pays for shipping expenses Shipping & Payment Details Contact us Postage - Insurance - Shipping Method Delivery

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